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The key residues in both GSH_a and GSH_b binding modes are located in the C1 region (N259 and E255), it is evident that for GSH, the C1 region of mTYR is the critical binding area

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Also, NSAIDs can adversely influence blood pressure regulation by interfering with renal prostaglandin synthesis, especially when used concurrently with angiotensin-converting enzyme (ACE) inhibitors, diuretics, and -blockers (Whelton 1999