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Although it is not included in the diagnostic criteria of PCOS, there is a crucial role of this metabolic impairment, which along with hormonal abnormalities, increase each other in a vicious circle of PCOS pathogenesis

Consequently CJC 129 without DAC is designed to provide a GHRM-like stimulation around the clock with increased amplitude and longer stimulation, (28 minutes instead of 8-12 of sermorelin), maintaining the natural pulsatile stimulation of the pituitary without decreasing secretion as observed in CJC with DAC

doi: 10.1080/1354750X.2021.2016972 97 RoepkeMDiestelABajboujKWalluscheckDSchonfeldPRoessnerAet al

Since it works through mechanisms distinct from both BPC-157 and TB-500, it theoretically complements both without redundancy

For more pronounced changes, such as significant skin brightening and the fading of hyperpigmentation, consistent treatment over three to six months is often required