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Vitamin C (ascorbic acid) is itself a potent water-soluble antioxidant, and just as importantly, it helps regenerate oxidised glutathione back into its active form

The antioxidants alpha-lipoic acid and N -acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice

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in-vitro study found that berberine protected NSC34 cells from H 2 O 2 -induced cytotoxicity by reducing ROS production, restoring glutathione, and superoxide dismutase activity, and activating the production of antioxidant proteins nuclear factor erythroid 2-related factor-2 (Nrf2) and HO-1 ( Studies have found that berberine has an antidepressant effect (Figure 1)

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