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Clinical trials should assess whether GLP-1RAs possess a protective effect against SA, and the underlying mechanisms should be elucidated in further studies

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Individual results vary, and outcomes are not guaranteed

Although VSMCs and the kidney play integral roles in BP regulation, there were no baseline differences in systolic, diastolic, or mean arterial pressure (MAP) between Glp1r VSM+/+ and Glp1r VSM/ mice, despite a marked reduction in kidney and renal artery Glp1r expression in Glp1r VSM/ mice (Figure 2, AC)

These findings collectively suggest that BPC 157 has a favorable safety profile, making it a promising candidate for further clinical studies