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Alcohol and Caffeine: Alcohol provides high calories with no nutritional benefit and can impair judgment, leading to poor food choices

Severe gastrointestinal disease, particularly gastroparesis, may alter both efficacy and tolerability and requires careful consideration

Problem: Side effects worse than expected at 7.5 mg If nausea, fatigue, or GI effects are significantly worse than at 5 mg, consider whether you might have drawn more than intended

Most tirzepatide injection site reactions appear within hours of injection, peak at 24-48 hours, and resolve spontaneously within 3-5 days

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