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Theriogenology 65, 18131827

Excess ROS activates inflammasome pathways, including NLRP3 inflammasome, promoting pyroptosis, an inflammatory form of cell death (Fig

It is comparable to a duodenal switch, a complex bariatric surgery that reduces stomach size and reroutes the small intestine

[246] showed that Nrf2 inhibition increased oxidative stress and aggravated hypertension in mice, whereas Nrf2 activation alleviated hypertension during Ang II infusion, highlighting its therapeutic relevance.Mitochondrial dysfunction, including impaired energy metabolism, increased mtROS, and mtDNA damage, amplifies ferroptosis and worsens endothelial injury [247, 248]

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