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These findings shed light on mechanisms underlying 5FU resistance and propose a rational strategy for combination therapy in CRC, emphasizing the potential clinical benefit of targeting mitochondrial metabolism to overcome resistance and enhance patient outcomes

234 Benfotiamine may improve neuropathic symptoms by reducing UDP-GlcNAc production

116 Astrocytic asthenia is also manifested by the limited reactivity in the most vulnerable brain regions such as entorhinal and prefrontal cortices in which astrocytes do not mount a defence response in the presence of -amyloid depositions

The liver metabolizes alcohol at a relatively constant rate, and the body requires time for this process