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2A (top), we noted in some patients a concentration-dependent negative inotropic effect followed by a positive inotropic effect

Oral Semaglutide and Cardiovascular Outcomes in Patients With Type 2 Diabetes (PIONEER 6) New England Journal of Medicine Demonstrated cardiovascular safety of oral semaglutide 14 mg daily versus placebo in 3,183 high-risk T2DM patients, with trend toward all-cause mortality reduction