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Beyond rebuilding, the peptide regulates matrix metalloproteinases (MMPs) in a way that clears out damaged tissue while protecting new collagen from breakdown

The rightward shift in the relaxation curve of AF-FMT vessels is indicative of a disruption in the endothelial mediated signaling necessary for vasorelaxation 39

Notably, GPx4, a downstream target of Nrf2, is localized in mitochondria and cytoplasm, where it scavenges lipid peroxide (lipid ROS) and suppresses ferroptosis

661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively