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The KAR-binding HTLs (ShHTL1, ShHTL3, and AtHTL) had smaller pockets than the D14 group and ShHTLs of the divergent clade due to more bulky and hydrophobic residues

Locally acting autocrine/paracrine molecules in the growth plate include Indian hedgehog (Ihh), parathyroid hormone-related protein (PTHrP), fibroblast growth factors (FGFs) (including FGF1, 2, 9 and 18), bone morphogenic proteins (BMPs) (including BMP27), vascular endothelial growth factor (VEGF), IGF-1, and Wnt [2,11,81,85,86,89,90]

doi: 10.1038/nclimate1958 53 REgseggerA.SchmutzD.BrunoldC

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Hod, A.M