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Consistent with this, the GLS inhibitor telaglenastat (CB-839) has entered phase I/II combination studies with immune checkpoint inhibitors such as nivolumab, reflecting a typical translational closed loop of amino acid metabolism-targeted drugcombination immunotherapyclinical safety and efficacy signal evaluation (119)

The microbiota can influence host pathophysiology by producing molecules that directly alter metabolism and/or modulate cellular signaling either locally in the gut or systemically via the circulation 1,2

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