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Its clinical evidence for weight loss demonstrates superior efficacy compared to GLP-1R mono-agonists, a difference rooted not merely in additive peripheral effects but in central neural synergy

Without sufficient protein intake, a greater proportion of weight loss may come from lean tissue rather than fat

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Replicates, randomization and blinding In vivo studies were performed in male or female age-matched mice that were randomly distributed to achieve groups of equal body weight and body composition