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A vicious cycle is created stress prevents sleep, and a lack of sleep generates even more stress
Glucocorticoid-Related Signaling and Side-Effect Models Glucocorticoids, while clinically valuable in many inflammatory and immune-mediated conditions, can induce catabolic side effects: Catabolism and Tissue Integrity: Prolonged glucocorticoid exposure is associated with muscle wasting, increased fat accumulation, and reductions in bone density in experimental systems
Casares, F., Bender, W., Merriam, J., and Sanchez-Herrero, E., "Interactions of Drosophila Ultrabithorax Regulatory Regions with Native and Foreign Promoters", Genetics 145: 123-137 (1997)