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The synthesis of glutathione involves a complex series of enzymatic reactions, with the rate-limiting step catalyzed by -glutamylcysteine synthetase

APAP activation would be shown to be catalysed mainly by CYP2E1, CYP1A2 and CYP3A4, with CYP2E1 predominating at high concentrations

Related in-vitro work reported increased integrin expression and p63 positivity in keratinocyte culture

A decrease in LDH indicates abnormal energy metabolism, with inhibited glucose oxidation for energy supply

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