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Pembrolizumab for early triple-negative breast cancer

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Simo S, Gomes P, Pinho MJ, Soares-da-Silva P

Secondly, hyperglycemia-driven mitochondrial dysfunction promotes the accumulation of the TCA cycle intermediate succinate, which inhibits prolyl hydroxylases (PHDs) and stabilizes HIF-1, a master transcriptional regulator that enhances the expression of IL-1 and other M1-associated inflammatory mediators, creating a feed-forward inflammatory loop (Tannahill et al., 2013

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