New England Journal of Medicine , 387(24), 2245-2257
Our clinician team can help determine if these treatments are right for your diabetes management plan
Clinical trials such as the STEP programme (semaglutide) and SUSTAIN studies show that: Initial weeks : Modest weight loss primarily from reduced caloric intake Months 23 : More noticeable reduction becomes evident Months 36 : Continued steady weight loss as dose escalates Months 612 : Peak weight loss approaches, with most studies showing maximal effect by 1218 months It is important to recognise that GLP-1 medications require dose titration starting at a low dose and gradually increasing over several weeks according to the specific product's SmPC
Per Trimi's published Refund Policy (last updated June 17, 2026): you need to stay on a continuous paid plan for six full months, take the medication as directed, log both a starting weight and a 6-month weight in the patient portal, and complete provider check-ins
The strongest determinants of engagement and trust included cost, access to knowledgeable and respectful providers, and culturally relevant care , which was particularly important for Black and Hispanic consumers