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Oxidized PAC-quinone imine metabolites have also been shown to form GSH-conjugates which inhibit glutathione reductase (GR): the decreased activity of GR hampers the detoxification and antioxidant capacity of the GSH-GSSG cycle, further aggravating the pro-oxidative status in the cell (Ndlov et al., 2014)

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Not getting enough vitamin B12 can cause neurological, physical, and psychological issues (7) and include: Neurological Problems Tingling of the hands and feet Nerve damage Numbness Memory loss Confusion Speech problems Physical Problems Exhaustion Weakness Nausea Loss of appetite Diarrhea Vomiting Weight loss Sore mouth Erectile dysfunction Headaches Psychological Problems Depression Irritability Not feeling like yourself Diagnosing a vitamin B12 deficiency isn't easy because symptoms may be considered to be related to other health issues, so if you think you could be experiencing signs, it's crucial to talk with your health practitioner to get tested