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Similar recommendations were made by the European Medicines Agency (EMA) that required including major adverse cardiovascular events (MACE) as a primary endpoint ( These regulatory requirements led to the discovery of cardiovascular benefits in GLP-1R agonists, demonstrating the importance of due diligence and proactive safety monitoring

For practitioners prescribing, patients receiving, and people choosing to purchase these medications privately, it's important to understand the risks of rapid weight regain if treatment ceases - and the value of wraparound behavioural support.' The researchers note several limitations

Why 4 week intervals matter The 4 week escalation interval was not chosen randomly

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