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Blood was collected from the tail vein and blood glucose levels was measured before the injection and 4, 8, 10, 24 and 48 h after dosing in fed conditions

In addition, most risk factors exhibit considerable heterogeneity across histologic subtypes of EOC 4

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This combination of effects leads to reduced calorie intake, which is the primary mechanism behind the significant weight loss observed in clinical trials

Waist circumference remains a practical clinical proxy for internal risk, with thresholds of 35 inches for women and 40 inches for men associated with higher metabolic complications, even when outward appearance appears normal