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The main rationale is that targeting multiple pathways would improve efficacy and therapeutic index 56

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Exclusion criteria: Patients with acute viral hepatitis, immune hepatitis, Wilson disease , concurrent conditions in which free radical production is elevated like other inflammatory processes outside the liver or intake of antioxidant drugs affecting free radical scavenging such as vitamin C, A and E at time of biopsy

61 The investigators calculated the proportional report ratio for GLP-1 RA and thyroid cancer and found the thresholds for reporting a new safety signal were fulfilled for exenatide, liraglutide, and dulaglutide as thyroid cancer was reported relatively more frequently with these drugs compared with all other drugs in the database