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Use sterile water only when specifically instructed or for immediate single-use applications

They are generally well tolerated and considered safer than synthetic HGH

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Additionally, while the total discontinuation rates were not reported, the proportion of patients receiving active treatment who discontinued due to adverse events was 10% in the LEADER trial of liraglutide (median follow-up 46 months) and 12% in the PIONEER 6 trial of oral semaglutide (median follow-up 15.9 months)