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95, e28399

The Journal of Nutritional Biochemistry, 11 (2), 109113

The trans-3-hexenoic acid group sterically shields the N-terminal region from dipeptidyl peptidase IV (DPP-IV) cleavage, which is the primary route of GHRH degradation in vivo, resulting in meaningfully improved metabolic stability compared to native GHRH and sermorelin

In hepatocellular carcinoma, the combination of m6A inhibitors with sorafenib or lenvatinib reverses drug resistance ( 6.2 The SSP as a key metabolic pathway mediating resistance to conventional chemotherapy and targeted therapy The SSP serves as a pivotal metabolic pathway that mediates tumor resistance to conventional chemotherapeutic agents and targeted therapeutics