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Circulation 2024;150(22):1781-1790

Why Protein and Muscle Preservation Matter When Side Effects Appear GLP-1 therapy can reduce appetite in a helpful way, but appetite suppression can become a problem if the patient consistently eats too little

Tirzepatide has a longer pharmacokinetic profile, so a longer initial assessment window is appropriate

This decrease could encourage osteoblast development and differentiation, which would benefit the skeleton (69)

Moreover, information on certain patient-level factors (e.g., race/ethnicity) and granular clinical details (e.g., HbA1c levels), which may influence the observed associations, was lacking