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Experimental irradiation leads to a decrease of renal CYP epoxygenases and urinary EET levels, to endothelial and vascular damage with afferent arteriolar dysfunction and impaired autoregulatory responses in the kidney

This is perfectly normal

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Birn H, Willnow TE, Nielsen R, Norden AGW, Bnsch C, Moestrup SK, Nex E, Christensen EI

The combination has one preclinical synergy paper but no human trial data of its own