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This study documented four patients who developed allodynia while taking semaglutide 2.4 mg subcutaneously once weekly for weight management

Participants were also assessed at weeks 52 and 78 to assess durability of glucose lowering with the two treatment approaches

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One study found that in NRXN1 +/- human induced pluripotent stem cell (hiPSC)-derived neurons, there was a significant increase in expression of novel NRXN isoforms, coupled with a decrease in the wild-type NRXN isoform [179]

We chose to base the main analysis on the HolmBonferroni correction, as this is more conservative than the FDR