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doi: 10.3389/fphar.2026.1752204 Received 22 November 2025 Revised 15 April 2026 Accepted 21 April 2026 Published 15 May 2026 Volume 17 - 2026 Edited by Sathish Kumar Natarajan, University of Nebraska-Lincoln, United States Reviewed by Fabio Vivarelli, University of Bologna, Italy Vijay Radhakrishnan, University of Missouri, United States Updates Copyright 2026 Mahalingam, Kharbanda, Casey and Rasineni

Second, and this is just as important, the cold environment itself creates a hostile setting for any potential microbial contaminants that might have been introduced

Grey-market quality varies

Tiny mineral crystals, such as uric acid or calcium oxalate, can appear due to nutritional factors or concentrated urine, but in higher amounts, they may signal kidney stone formation

Consider combinations after lifestyle therapy and single-agent trials