The concern, as with any combination of appetite-affecting medications, is ensuring patients are consuming enough total calories and protein to support muscle preservation and metabolic health during weight loss
When NAD drops, so does mitochondrial performance, leaving you with slower metabolism, mental fog, and that mid-day crash we hear about so often
In the primary Phase 2 clinical trial published in the New England Journal of Medicine (Jastreboff et al., 2023), retatrutide was studied across several dose levels, including: 1 mg (low dose) 4 mg (mid dose) 8 mg (higher dose) 12 mg (highest dose) These doses were administered as once-weekly subcutaneous injections
Also, track your symptoms
This distributes the medication more evenly through the tissue