glp-1 liver Simplified summary of the biological actions of GIP and as Frontiers | GLP-1 Receptor Agonists:

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The gastrointestinal side effects result directly from the drug's mechanism of slowing gastric emptying and affecting gut motility

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thats why its called active. Active transport is the use of chemical energy (ATP in this case) in order to move solution against the concentration gradient

Less Common but Noteworthy Side Effects While most side effects from GLP-1 medications are mild and manageable, some patients may experience more serious side effects that require close monitoring