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Some users report a skin purging phase during the first 1 to 2 weeks of topical use

Interestingly, differences in prooxidative parameters were more profound in acute coronary syndrome patients compared with coronary artery disease patients indicating that the acute form of coronary artery disease is more susceptible to oxidative damage, suggesting that use of antioxidant therapy may be warranted to reduce oxidative stress in this disorder (154)

Chang, X., Liang, Y., Shi, F., Guo, T

The earliest studies suggested that DSIP could selectively enhance delta-wave activity during NREM sleep