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Metabolization and/or conjugation of toxins, carcinogens and xenobiotics This is the removal of harmful, chemical substances that do not naturally occur in the body, or other substances that have reached dangerously high levels

10.1016/j.regpep.2012.12.007 4 BecejacT.CesarecV.DrmicD.HirslD.MadzaracG.DjakovicZ.et al (2018)

Safety Considerations: GLP-1 Use and Surgical Risk Factors GLP-1 medications like semaglutide carry a well-documented safety profile in non-surgical populations, but certain surgical scenarios warrant extra caution

Tapering is also not universally feasible

"Comparative Bioavailability and Utilization of Particular Forms of B12 Supplements With Potential to Mitigate B12-related Genetic Polymorphisms"