The characteristics of glutathione are the following: (a) discovered by Hopkins in 1921 [67], (b) synthesized intracellularly by glutamate-cysteine ligase and glutathione synthetase [68], (c) exists in reduced (GSH) and oxidized (GSSG) forms, maintaining cellular redox balance [69], (d) functions in melanogenesis inhibition through tyrosinase suppression and pheomelanin synthesis [70], and (e) oral bioavailability is enhanced through liposomal formulations, S -acetyl derivatives, or co-administration with precursors [71]
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13.3.3 Undesirable metabolic events A key safety concern is the potential of probiotics, particularly those closely related to pathogenic species, to serve as vectors for horizontal transfer of antibiotic resistance genes to indigenous gut microorganisms
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& Ankathil, R
