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The conversion of heme to heme has been studied in by many scientists, and it is proposed that the oxidation of heme in HPII may be catalyzed by HPII itself

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Investigations of blood UA have consistently indicated associations between reduced UA and PD, confirmed in a recent meta-analysis of cohort studies 12

GI symptoms, including excessive salivation, dysphagia, constipation, esophageal motility disorders, and gastric abnormalities, occur many years before the appearance of motor symptoms and may be associated with an increased risk of developing PD [112]