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Patatin-like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C

The two work through different mechanisms and may produce additive benefits

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The downstream effects of activating these receptors produce a coordinated set of responses that collectively reduce body weight

This provides multiple determinants of aberrant signalling, cell-cell interaction networks leading dynamically to cell transformation, clonal selection, immune response delay, immune surveillance suppression and tumorigenesis (85)