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It found that glucagon-like peptide-1 receptor agonists (GLP-1 drugs) like Ozempic may be linked to lower depression risk compared to other diabetes drugs, particularly dipeptidyl peptidase-4 inhibitors ( DPP4i ) like Januvia

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A longitudinal study published in 2026 found that baseline microbiome composition predicted glycemic response to semaglutide even in the absence of significant changes in microbiome diversity during treatment consistent with the hypothesis that response determinants are partly established before drug initiation (Dinkov & Pendicheva-Duhlenska, 2026)