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Subcutaneous: B12 Injection Procedure Administering a subcutaneous B12 injection follows a similar process to intramuscular injections but involves injecting the B12 solution into the fatty layer of tissue just beneath the skin

Most of the data come from animal studies or small, open label reports

other allergic reactions that have been reported include erythema, skin rash (unspecified), pruritus, general malaise, and respiratory difficulty due to bronchospasm

Vitamin B12 is water-soluble, meaning excess amounts are naturally flushed from the body