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Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor- coactivator 1 regulated -secretase 1 degradation and mitochondrial gene expression in Alzheimers mouse models

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Restoration of DJ-1 expression ameliorates these defects by enhancing mitochondrial electron transport chain activity and reducing ROS overproduction, thereby attenuating oxidative stress-mediated neuronal damage (McCoy and Cookson, 2011)

68, 70 The mucin protein family itself is highly diverse and contains membrane-anchored or -secreted proteins with diverse functions, including regulation of the barrier function and epithelial cell homeostasis