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Possible with high doses or excessive frequency: Downregulation Chronic high exposure reduction LHCGR expression Prevention Physiological doses (500-1500 IU 2-3x/week) Signs Decreased testosterone response, requires increasing doses Recovery Rest 4-8 weeks to restore sensitivity Main side effects research

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A week-long gap during weeks 1 through 4 of loading could delay the tissue saturation that makes maintenance effective

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