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*Correspondence: Ke Jiang, [email protected] Zheng, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

For example, due to the impact of first pass metabolism, some studies suggest approximately 5x greater bioavailability via the buccal route as compared to the oral route of administration

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