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Impurities in peptide preparations can include synthesis byproducts, degradation products, or contamination from manufacturing

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We thank the commenter for their suggestion to convene a stakeholder group to evaluate the use and display of allowed amounts within the MRF and to continue to allow flexibility until we do, but decline the commenter's suggestion at this time as we believe we have received sufficient feedback on encoding allowed amounts within the MRF via the public comment period on the proposed rule as well as in response to the CMS Hospital Price Transparency Accuracy and Completeness Request for Information (the public comment period for which closed on July 21, 2025), in which commenters recommended hospital MRFs should list a precise dollar amount for items and services whenever possible