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Beyond metabolism and structure, copper promotes angiogenesis by stabilizing hypoxia-inducible factor-1 (HIF-1) via transporters such as Copper Transporter 1 (CTR1

It occurs naturally in human plasma, with levels that decline with age

The apparent lack of a direct effect was noted due to the in vitro environment not mimicking the inherent environment of a tendon in vivo

Takeaway: If peptides were tools, GHK-Cu would be the precision paintbrush that perfects the finish after the heavy lifting is done

Proc Natl Acad Sci U S A 95:84048409 Biterova EI, Barycki JJ (2009) Mechanistic details of glutathione biosynthesis revealed by crystal structures of Saccharomyces cerevisiae glutamate cysteine ligase