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12 In addition, propionate is an end-product of fermentation and thus is not cross-metabolised by the microbiota unlike acetate and butyrate

This is particularly important for people with underlying conditions, such as kidney disease or a history of thyroid issues

Do not use Zepbound if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC)

Classification and differential diagnosis of diabetic nephropathy

Weight loss is not guaranteed and is influenced by many factors, including diet, exercise, and individual biology." The brand-reported "up to 25% body weight reduction" figure is a ceiling cited in the context of program-wide data, not a guarantee of individual outcomes