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Int J Mol Sci 23:321335 Han Y-G, Qin X, Zhang T, Lei M, Sun F-Y, Sun J-J, Yuan W-F (2018) Electroacupuncture prevents cognitive impairment induced by lipopolysaccharide via inhibition of oxidative stress and neuroinflammation
Methods The current study involves the fusion of a native or mutant GLP-1 (30 residues) with an HSA-binding DARPin (123 residues) via a rigid helical linker (15 residues) to create fusion proteins (168 residues) resistant to DPP-IV and, or trypsin with extended half-lives using structural modeling, which are subsequently characterized using MD simulation and molecular docking analyses
Biodistribution of gold nanoparticles and gene expression changes in the liver and spleen after intravenous administration in rats