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10.1098/rspb.2019.0800 45 EisenbergD

Aksit, M

Follow-Up Visits and Outcomes Three-Month Check Weight: Down 3 kg (BMI 34 kg/m) HbA1c: Decreased to 7.8% from 8.6% Blood Pressure: Controlled at 128/80 mmHg Side Effects: Mild nausea during the first few weeks, which subsided with slow dose titration Six-Month Check Weight: Down a total of 6 kg (BMI 33 kg/m) HbA1c: Further improvement to 7.3% Cardiometabolic Indicators: Mild improvement in LDL cholesterol (from 110 mg/dL to 98 mg/dL)

Silenced plants exhibited loss of red pigmentation in the leaves, confirming the functionality of the system, although the phenotype was not inherited in the seed coat of progeny