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Antioxidants play a crucial role in mitigating the damaging effects of free radicals on cells

[53] The manufacturer recommends pregnancy be ruled out two weeks before commencement of isotretinoin, and women should use two simultaneous forms of effective contraception at least one month before commencement, during, and for at least one month following isotretinoin therapy

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Severity of Deficiency : Severe deficiencies often require injections to restore B-12 levels quickly