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Drink 200 to 300 mL of fluid every 15 to 20 minutes during exercise, not just when you feel thirsty

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Transdermal estradiol, delivered through patches or gels rather than oral tablets, bypasses the liver entirely, avoiding the first-pass hepatic metabolism that oral estrogen undergoes and that is associated with increased clotting factor production and thrombotic risk

Patino W, Thomas A, Jain S, Del Rosso JQ, Issa NT