Weakness and numbness in the hands and feet: Vitamin B12 deficiency can cause nerve damage, which can result in numbness or tingling in the hands and feet, as well as muscle weakness
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p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
Additionally, a case report of a child with autistic disorder and cerebral folate deficiency showed the normalisation of low cerebral spinal fluid homocysteine following 2 weeks supplementation with 0.5 mg folinic acid/kg/day increasing to 1.0/kg/day for 3 months [54]
Hence, the higher antioxidant capacity of children and young adults combined with their higher expression of ACE2 is the likely explanation for the low incidence of severe infections in these age groups