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[126] demonstrated that STAT3 signaling activated the expression of IDO, a major inducer of the immunosuppressive milieu, without the need for binding of STAT3 protein to the promoter of IDO gene in human MDSCs

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thromboxane A2 (TXA2): a substance produced primarily by platelets (via COX-1) that causes vasoconstriction and promotes platelet aggregation

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Individuals with chronic fatigue syndrome, fibromyalgia, or mitochondrial disorders may report subjective improvements, although high-quality evidence is lacking