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Yang R, Otten MA, Hellmark T, Collin M, Bjrck L, Zhao MH, et al

This might be due to blocking active microglia, as shown in mouse models of ALS (Barreto-Nez et al., 2024)

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Patients with a severe needle phobia, tremors, poor eyesight, or cognitive impairment should have a partner, family member, or healthcare provider administer the injection instead

Moreover, the percentage of participants in clinical trials who stopped the treatment due to AE was 515% with most of the new agents, and this percentage was up to 2030% with some of GLP-1/glucagon RA in phase 2 trials so a considerable proportion of people may not be able to tolerate the new obesity pharmacotherapies or may be unable to titrate them to the higher and most effective doses