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In Phase 3 studies, retatrutide has been given as a once-weekly injection, usually starting at 2mg once weekly before increasing gradually every four weeks

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No randomized human trial has established a clinically validated dose all protocols derive from animal data and clinician case series, principally the Sikiric et al

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doi:10.1016/j.brainres.2023.148290 Buzga, M., Machytka, E., Dvorackova, E., et al