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As a prospect to achieve permissions for clinics, more extensive researches such as investigation of the effects of MVs on other skin cells (such as keratinocytes), identification of the whole internal and surface components of MVs (such as miRNAs, other mRNAs, and proteins), and preclinical evaluations of reverse-engineered MVs on skin regeneration are promising

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All of these diseases are determined by the deposition of S aggregates, but can be separated into distinct pathological phenotypes and diagnostic criteria [254]